Krazy Kat gets its start as a literally "low" plot at the bottom of another strip.

George Herriman, The Dingbat Family, cartoon, 26 July 1910; rpt. in Patrick McDonnell, Karen O'Connell, Georgia riley de Havenon, Krazy Kat: The Comic Art of George Herriman (New York: Harry N. Abrams, 1986), 55.